姓名：胥宁

职称：副研究员

学位：博士

邮箱：xuning@yfi.ac.cn

研究方向：水产药理学

教育经历：

2005/09-2012/06，华中农业大学，兽医药理与毒理学，硕士和博士

2001/09-2005/07，青岛农业大学，动物医学，学士

主要职历

2022/01至今，中国水产科学研究院长江水产研究所，水产信息与标准研究室，副研究员，所聘研究员

2021/01-2021/12，中国水产科学研究院长江水产研究所，水产信息与标准研究室，副研究员

2018/10-2019/10，美国堪萨斯州立大学计算药理研究所，访问学者

2013/03-2020/12，中国水产科学研究院长江水产研究所，水产品质量标准研究室，助理研究员

科研成果

主要论文（第一作者或通讯作者）

1.Xu, N., Li, M., Lin, Z., Ai, X. Comparative Pharmacokinetics of Sulfadiazine and Its Metabolite N4-Acetyl Sulfadiazine in Grass Carp (Ctenopharyngodon idella) at Different Temperatures after Oral Administration. Pharmaceutics, 2022, 14(4), 712.

2.Xu N, Sun W, Gong L, Liu Y, Dong J, Yang Y, Zhou S, Ai X. Comparative pharmacokinetics of doxycycline in crayfish (Procambarus clarkii) following oral, intramuscular, and intrasinus administrations. Aquaculture, 2022, 551: 737941.

3.Sun W, Chang C, Xu N ⃰, Wu J, Liu Y, Dong J, Zhou S, Yang Y, Yang Q, Ai X. Determination of doxycycline’s plasma protein binding rates in the plasma of grass carp (Ctenopharyngodon idella), yellow catfish (Pelteobagrus fulvidraco) and crayfish (Procambarus clarkii) by an ultrafiltration method at different temperatures with different concentrations. Aquaculture Research, 2022, 53: 2865-2873.

4.Ning Xu, Yu Fu, Xiaomei Zhang, Yongtao Liu, Yibin Yang, Shun Zhou, Jing Dong, Qiuhong Yang, Xiaohui Ai*. The pharmacokinetic characteristics of sulfadiazine in channel catfish (Ictalurus punctatus) following oral and intravenous administrations. Journal of Veterinary Pharmacology and Therapeutics, 2022, 45(1):16-22.

5.Ning Xu, Bo Cheng*, Miao Li, Zhoumeng Lin, Xiaohui Ai. Withdrawal interval estimation of doxycycline in yellow catfish (Pelteobagrus fulvidraco) using an LC-MS/MS method based upon QuEChERS sampling preparation. Foods, 2021, 10(11): 2554.

6.Ning Xu, Miao Li, Xiaohui Ai*, Zhoumeng Lin*. Determination of pharmacokinetic and pharmacokinetic-pharmacodynamic parameters of doxycycline against Edwardsiella ictaluri in yellow catfish (Pelteobagrus fulvidraco). Antibiotics, 2021, 10(3): 329.

7.Ning Xu, Yu Fu, Fang Chen, Yongtao Liu, Jing Dong, Yibin Yang, Shun Zhou, Qiuhong Yang, Xiaohui Ai. Sulfadiazine pharmacokinetics in grass carp (Ctenopharyngodon idellus) receiving oral and intravenous administrations. Journal of Veterinary Pharmacology and Therapeutics, 2021, 44(1): 86-92.

8.Ning Xu, Yu Fu, Bo Cheng, Yongtao Liu, Qiuhong Yang, Jing Dong, Yibin Yang, Shun Zhou, Yi Song and Xiaohui Ai. The pharmacokinetics of doxycycline in channel catfish (Ictalurus punctatus) following intravenous and oral administrations. Frontiers in Veterinary Science, 2020, 7: 577234.

9.Ning Xu, Miao Li, Wei-Chun Chou, Zhoumeng Lin. A physiological based pharmacokinetic model of doxycycline for predicting tissue residues and withdrawal intervals in grass carp (Ctenopharyngodon idella). Food and Chemical Toxicology, 2020, 137,111127.

10.Ning Xu, Miao Li, Yu Fu, Xiaomei Zhang, Xiaohui Ai, Zhoumeng Lin. Tissue residue depletion kinetics and withdrawal time estimation of doxycycline in grass carp, Ctenopharyngodon Idella, following multiple oral administration. Food and Chemical Toxicology, 2019, 131: 110592.

11.Ning Xu, Miao Li, Yu Fu, Xiaomei Zhang, Jing Dong, Yongtao Liu, Shun Zhou, Xiaohui Ai, Zhoumeng Lin. Effect of temperature on plasma and tissue kinetics of doxycycline in grass carp (ctenopharyngodon idella) after oral administration. Aquaculture, 2019, 511: 734204.

12.Ning Xu, Jing Dong, Yibin Yang, Yongtao Liu, Qiuhong Yang, Xiaohui Ai. Development of a liquid chromatography–tandem mass spectrometry method with modified QuEChERS extraction for the quantification of mebendazole and its metabolites, albendazole and its metabolites, and levamisole in edible tissues of aquatic animals. Food Chemistry, 2018,269:442-449 (IF=9.2).

13.Ning Xu, Jing Dong, Zhou Wei, Yongtao Liu, Xiaohui Ai. Determination of Doxycycline, 4-epidoxycycline, and 6-epidoxycycline in Aquatic Animal Muscle Tissue by an Optimized Extraction Protocol and Ultra-performance Performance Liquid Chromatography with Ultraviolet Detection. Analytical Letters, 2018, 52(3): 452-464.

14.Ning Xu, Jing Dong, Yibin Yang, Xiaohui Ai. Pharmacokinetics and depletion of praziquantel in rice field eel (Monopterus albus). Diseases of Aquatic Organisms. 2016, 119: 67-74.

15.Ning Xu, Jing Dong, Yibin Yang, Qiuhong Yang, Yongtao Liu, Xiaohui Ai. Pharmacokinetics and bioavailability of flumequine in blunt snout bream (Megalobrama amblycephala) after intravascular and oral administrations. Journal of Veterinary Pharmacology and Therapeutics. 2016, 39(2):191-195.

16.Ning Xu, Binbin Gong, Jing Dong, Yibin Yang and Xiaohui Ai. Single intravascular and oral dose pharmacokinetics of mebendazole in blunt snout bream, Megalobrama amblycephala. Journal of the World Aquaculture Society, 2016, 47(5):685-690.

17.Ning Xu, Xiaohui Ai, Yongtao Liu, Qiuhong Yang. Comparative pharmacokinetics of norfloxacin nicotinate in common carp (Cyprinus carpio) and crucian carp (Carassius auratus) after oral adminiatration. Journal of Veterinary Pharmacology and Therapeutics. 2015, 38 (3):309-312

18.Huang Lingli1, Xu Ning, Sechenchogt Harnud1, Pan Yuanhu, Chen Dongmei, Tao Yanfei, Liu Zhenli, and Yuan Zonghui. Metabolic Disposition and Elimination of Cyadox in Pigs, Chickens, Carp, and Rats. Journal of Agricultural and Food Chemistry, 2015, 63 (22), 5557–5569.

19.Ning Xu, Lingli Huang, Zhenli Liu, Yanhu Pan, Xu Wang, Yanfei Tao, Dongmei Chen, Yulian Wang, Dapeng Peng, Zonghui Yuan﹡. Metabolism of cyadox by the intestinal mucosa microsomes and gut flora of swine, and identification of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Rapid Communication in Mass Spectrometry. 25 (16): 2333-2344, 2011.

20.胥宁，郑全辉，刘永涛，周顺，杨移斌，董靖，杨秋红，艾晓辉.甲苯咪唑在团头鲂体内的物料平衡.华中农业大学学报，2022, 41(2): 185-190.

21.胥宁，杨移斌，刘永涛，董靖，杨秋红，艾晓辉. 混饲对吡喹酮在草鱼体内药动学和生物利用度的影响. 淡水渔业，2018, 5: 73-78

22.胥宁，刘永涛，杨秋红，艾晓辉. 喹烯酮在草鱼体内生理药动模型的建立.水生生物学报，2015，39（3）：517-523．

23.胥宁，刘永涛，艾晓辉，赵凤，杨秋红，吕思阳. 甲苯咪唑在团头鲂体内主要代谢物及其变化规律研究.淡水渔业，43（6）：42-46，2013.

授权发明和实用新型专利

1.胥宁，艾晓辉，董靖，刘永涛，杨移斌，杨秋红. 水产品中苯并咪唑及噻唑类残留药物的快速提取及LC-MS-MS检测方法. ZL 201710222141.1

2.胥宁，艾晓辉，董靖，周伟，刘永涛，谌芳. 水产品中多西环素及代谢产物的快速提取及检测方法. ZL 201810390452.3

3.胥宁，艾晓辉，杨秋红，刘永涛，董靖，杨移斌. 一种生理药动学模型预测草鱼组织中药物残留的方法. ZL201410537997.4

4.胥宁，艾晓辉，董靖，刘永涛，张晓梅，付钰.一种鱼类背主动脉插管.ZL 201820629267.0.

5.胥宁，艾晓辉，董靖，杨移斌，刘永涛，杨秋红. 一种适于鱼类生理参数测定的实验装置.ZL 201720042733.0

获奖成果

1.稻田小龙虾绿色高效养殖和质量安全控制关键技术与应用，湖北省科技进步二等奖，2021年，第七完成人

2.典型养殖鱼类药物代谢残留规律及模型预测技术研究，中国水产科学研究院科学技术奖二等奖，2021年，第5完成人

3.斑点叉尾鮰安全生产关键技术, 湖北省科技进步二等奖, 2014年, 第10完成人

4.斑点叉尾鮰安全生产关键技术, 中国水产科学研究院科技进步二等奖, 2013年, 第10完成人

主持和参与主要项目

1.国家自然科学基金面上项目，基于生理药动学可视化界面对恩诺沙星及代谢物在鱼体休药期预测及外推，32173022，主持；

2.湖北省自然科学基金面上项目，基于生理药动学模型对多西环素在草鱼体内的残留预测，2019CFB636，主持；

3.国家留学基金委公派出国项目，渔药在鱼体内生理药动学模型的建立，201803260013，主持；

4.中国水产科学研究院基本科研业务费，基于PK/PD模型多西环素对鮰爱德华氏菌的防耐药突变研究，2017HY-ZC03，主持；

5.中国水产科学研究院基本科研业务费，吡喹酮在草鱼体内代谢，2015JBFM29，主持；

6.国家重点研发计划，水产品全链条关键危害物的迁移转化规律与安全防控技术研究子课题“典型养殖用药的迁移规律及防控技术”，2017YFC1600704，参与；

7.湖北省重大项目，虾-稻高效养殖与质量安全控制关键技术研究，2019ABA077，参与；

8.国家现代农业产业技术体系，特色淡水鱼产业技术体系质量安全岗位专家分解任务，参与。